Endothelium dysfunction and the inflammatory response play important roles in the process of AAD and AMI however, whether serum protein profiles reflect the different pathophysiological progression of AAD and AMI is incompletely explored.ĪAD patients, AMI patients, and normal subjects were consecutively enrolled from 2018 to 2019 in the Chinese Medical University Hospital (Taichung, Taiwan). AMI is commonly characterized by the accumulation of lipids and the resulting recruitment of inflammatory cells in the vascular endothelium. Similarly, acute myocardial infarction (AMI) is also a severe cardiovascular disease that may lead to sudden death and remains the leading cause of death around the world. According to the National Health Insurance Research Database in Taiwan, the 180-day mortality rate due to AD is as high as 22.8%. Several important risk factors, including long-term arterial hypertension, smoking, and dyslipidemia, have been known to result in aorta degeneration and the promotion of aortic wall fragility, which ultimately causes the structural damage of the aorta in response to blood flow and eventually leads to AAD. Collectively, these findings reveal the differential serum protein profiles between AAD and AMI, which may reflect the divergent pathophysiological progression between the two cardiovascular diseases.Īcute aortic dissection (AAD) is a life-threatening cardiovascular disease that was described as early as in the 18th century. In addition, the serum level of Cadherin-5, an identified protein with significant regulation in AAD, was further evaluated by ELISA and the results showed that Cadherin-5 in AAD sera was higher that in AMI and healthy sera. Bioinformatic analysis revealed that the differentially expressed serum proteins were mainly derived from exosomes and the extracellular space, and their molecular functions and biological processes were primarily involved in the activity of transporters and complements and the immune response. After depletion of albumin and IgG, a total of 117 proteins with differential expression (fold change ≥2 or ≤−2.0, p < 0.05) were identified, of which 60 were upregulated and 57 were downregulated in AAD sera as compared to AMI sera. Protein identities and expression levels were assessed by LC-MS/MS analysis and a label-free quantitation method, respectively. A total of 75 serum samples were collected, including AAD patients without AMI (n = 25), AMI patients without AAD (n = 25), and normal subjects (n = 25). Here, we aimed to explore serum protein profiles between AAD and AMI patients.
However, whether serum proteins are differentially expressed between AAD and AMI remains unclear.
Acute aortic dissection (AAD) and acute myocardial infarction (AMI) are both severe cardiovascular diseases that may cause sudden death.
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